canis, Advantage Multi for Dogs should be administered as a single topical dose. Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application of Advantage Multi for Dogs. In case of allergic reaction, contact a physician. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Food Residue Moxidectin has been shown to be safe in collie breeds and collie mixed breeds. Without treatment, this dog was neurologically normal at 24 hours and had a normal appetite by 48 hours post-dosing. (See ADVERSE REACTIONS.). Administering the same dose for three consecutive months increased the level of protection to 44.4%, higher than that achieved with a single dose of moxidectin at 12 µg/kg (33.3%) and approaching the efficacy of one dose at 24 µg/kg (53.2%) (Table 1); however, all dogs in all groups were infected with HW regardless of dose and regimen used. Dog medications dosage requirements are generally calculated by weight and measured in mg of medicine per pound of body weight. The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration Product Info For Dogs | Product Insert for Dogs Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. In a field safety and effectiveness study, Advantage Multi for Dogs was administered to 92 client-owned dogs with sarcoptic mange. LD50 acute, rats, dermal >5000 mg/kg As a general rule, dogs and cats tolerate imidacloprid very well. The treatment schedule should be based on individual veterinary diagnoses and on the local epidemiological situation. Field Study: A 56-day field safety study was conducted in 214 D. immitis heartworm and microfilariae positive dogs with Class 1, 2 or 3 heartworm disease. As specified in the following table, administer the entire contents of the Advantage Multi for Dogs tube that correctly corresponds with the body weight of the dog. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. If contact with skin or clothing occurs, take off contaminated clothing. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. (See ADVERSE REACTIONS and ANIMAL SAFETY - Safety Study in Heartworm-Positive Dogs.). People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin should administer the product with caution. Advantage Multi® is supplied for topical application in dogs and cats. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. Wash hands thoroughly with soap and warm water after handling. Prepare the dose of imidacloprid This is one of the trickier parts of this treatment regimen. Oral Safety Study in Beagles: Advantage Multi for Dogs was administered once orally at the recommended topical dose to 12 dogs. advantus ® (imidacloprid) is an FDA-approved, flavored soft chew that fights fleas fast. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. The IHC Group. The most common breeds associated with this mutation include Collies and Collie crosses. Effectiveness against circulating D. immitis microfilariae was > 90% at five of six sites; however, one site had an effectiveness of 73.3%. Once-a-month topical solution for the prevention of heartworm disease, the treatment of circulating microfilariae, kills adult fleas, is indicated for the treatment of flea infestations, the treatment and control of sarcoptic mange, as well as the treatment and control of intestinal parasite infections in dogs and puppies that are at least 7 weeks of age and that weigh at least 3 lbs. It is supplied as a topical solution that collects in the oils of the skin and in hair follicles. The following adverse events in dogs are listed in decreasing order of reporting frequency: depression/lethargy, vomiting, pruritus, diarrhea, anorexia, hyperactivity, ataxia, trembling, hypersalivation, application site reactions (alopecia, pruritus, lesions, and erythema), seizures, and anaphylaxis/anaphylactic reactions (hives, urticaria, facial swelling, edema of the head). advantus is available in two strengths: 7.5 mg for dogs weighing 4-22 lbs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Following the first treatment with Advantage Multi for Dogs alone, two dogs experienced adverse reactions (coughing, vomiting, and dyspnea) that required hospitalization. Multiply 0.045 times your dog’s weight for dose The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration. b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care. A second monthly dose may be administered if necessary. Updated: 2020-12-31. Both have the same formula containing 1.47 percent Imidacloprid just like the Bayer Tree and Shrub Insect Control. This drug combination is produced by Bayer is labeled to prevent. Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328, and 6,001,858. body weight. Following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride, the following adverse reactions were observed: Dogs Treated with Advantage Multi for Dogs Only n=106, Dogs Treated with Advantage Multi for Dogs + Melarsomine n=108. How it Works: Advantus Oral Flea Treatment Capsules for Dogs contain Imidacloprid, which safely and effectively kills fleas within one hour of administration and is 96% effective against adult fleas within 4 hours.The capsule is easy to give to your dog and may be given as an occasional dose when you see fleas on your pet or daily if necessary. The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. Spotted areas may appear wet or oily for up to 24 hours. How it Works: Advantus Oral Flea Treatment Capsules for Dogs contain Imidacloprid, which safely and effectively kills fleas within one hour of administration and is 96% effective against adult fleas within 4 hours.The capsule is easy to give to your dog and may be given as an occasional dose when you see fleas on your pet or daily if necessary. Assurity Plus Spot On's unique formula prevents heartworm disease in cats and dogs while controlling fleas, roundworms and hookworms and ear mites in both species and whipworms, Sarcoptes and Demodex mites in dogs. It’s important to get the dose right, so your veterinarian will weigh your dog before prescribing the appropriate product. Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites: Do not administer this product orally. Exposure to the product has been reported to cause headache; dizziness; and redness, burning, tingling, or numbness of the skin. Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs. Advantage Multi for Dogs is not effective against adult D. immitis. Overdose is rare and no adverse effects have been reported at even up to 5 times the recommended dose. Twist the cap to break the seal and then remove cap from the tube. Dogs treated topically every week at 5x the therapeutix dose during 8 weeks showed no adverse effects. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Dogs should be given within one month of the last dose of the former medication. 1. The dogs ranged in age from 2 months to 12.5 years and ranged in weight from 3 to 231.5 pounds. Veterinary formulations: Advantage Multi® (Bayer). It is not absorbed into the body and does not circulate through the blood stream. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Treatment of Circulating Microfilariae: For the treatment of circulating D. immitis microfilariae in heartworm-positive dogs, Advantage Multi for Dogs should be administered at one-month intervals. Do not let this product get in your dog’s mouth or eyes. Cats over 18 pounds should be treated with the appropriate combination of tubes. Six dogs vomited within 1 hour of receiving the test article, 2 of these dogs vomited again at 2 hours, and 1 dog vomited again up to 18 hours post-dosing. Advantage Multi for Dogs was used safely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, ophthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. The safety of Advantage Multi for Dogs has not been established in breeding, pregnant, or lactating dogs. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. The effects of imidacloprid last about 30 days and remain effective after bathing or swimming, though shampooing should be avoided within 48 hours of application. Administration to heartworm positive dogs can lead to a potentially severe shock-like reaction. One dog showed signs of treatment site irritation after application. ©Copyright 1999 - 2021. Serious reactions, including neurologic signs and death have been reported when cats have been exposed (orally and topically) to this product. Dogs in the treated group did not gain as much weight as the control group. In both groups, there were more adverse reactions to Advantage Multi for Dogs following the first treatment than the second treatment. Administer the entire contents of the Advantage Multi ® for Dogs tube that correctly corresponds with the body weight of the dog. Bayer HealthCare LLC, Animal Health Division, P.O. Note that dogs at the lower end of the weight ranges get twice this much, or even more for very small dogs. This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. Imidacloprid and moxidectin is not recommended for use in kittens less than 9 weeks of age or less than 2 pounds. Moxidectin is also a parasite control drug. The drug […] The signs in this dog may have been related to peak serum levels of moxidectin, which vary between dogs, and occur between 1 and 21 days after application of Advantage Multi for Dogs. If swallowed, call poison control center or physician immediately for treatment advice. Imidacloprid toxicity in dogs is rare, but can occur especially if your dog licks the imidacloprid. Do not dispense dose applicator tubes without complete safety and administration information. Children should not come in contact with application sites for two (2) hours after application. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. 15 Dogs fed up to 41 mg/kg of imidacloprid for a year developed increased cholesterol levels and increased concentration of cytochrome P450. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. 5. It is a different chemical than Frontline, but the same as the vet's Advantage product. Uses of Imidacloprid. (2.5 mg/kg) moxidectin once a month by topical administration. Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. Safety Study in Puppies: Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. Part the hair on the back of the dog between the shoulder blades until the skin is visible. No clinical abnormalities were observed. While generally safe and effective when prescribed by a veterinarian, imidacloprid + moxidectin may cause side effects in some animals. Be certain to complete the prescription unless specifically directed otherwise by your veterinarian. ● Children should not come in contact with application sites for two (2) hours after application. ● For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. The microfilariae count in some heartworm-positive dogs increased or remained unchanged following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride. Multiply 0.045 times your dog’s weight for more precise dosage. Imidacloprid and moxidectin should not be used in animals with known hypersensitivity or allergy to the drug. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. *Dose is 0.045ml/pound. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. To report a suspected adverse reactions, call 1-800-422-9874. Recommended dosage-Been using the Bayer tree & shrub, 1.47% imidicloprid product here since early spring. Advantage Multi™ is a combination of two drugs, imidacloprid and moxidectin, that act to treat or prevent a variety of parasites. One puppy in the 1X treatment group had pruritus for one hour following the fifth treatment. Dogs over 88 pounds should be treated with the appropriate combination of tubes. Avoid contact with skin. While holding the tube in an upright position, remove the cap from the tube. Turn the cap over and push the other end of cap onto the tip of the tube. The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. Advantage Multi for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). 37.5 mg Advantus Soft Chews contain 37.5 mg imidacloprid per chew for dogs 23 - 110 lbs. Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. Dermal Dose Tolerance Study: Advantage Multi for Dogs was administered topically to 8-month-old Beagle dogs at 10X the recommended dose once. Oral Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. Advantus (imidacloprid) Oral Dog Flea Treatment, Soft Flea Chews for Dogs 23-110 lbs, 30 doses 4.3 out of 5 stars1,395 K9 advantix II Flea and Tick Prevention for Medium Dogs, 11-20 … Parasitic infections are common and include external parasites (fleas, ticks, mites) and internal parasites (intestinal worms, lungworms, heartworms). 3. In dogs, injectable moxidectin is dosed at 0.023 mg per pound (0.05 mg/kg) intramuscularly every 6 months. __________________. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. and 37.5 mg for dogs weighing 23-110 lbs. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. The following adverse events are based on post-approval adverse drug experience reporting. For dogs weighing 20 lbs. Consult with your veterinarian to determine if other drugs your pet is receiving might interact with imidacloprid and moxidectin. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. If eye irritation develops or persists, contact a physician. Dogs should be older than 7 weeks of age and cats older than 8 weeks of age. Prevention: for the treatment and control of sarcoptic mange difficult breathing from 4 to 8 weeks of age less... Act to treat a variety of parasites, leading to their death but. Dogs following the first week irritation after application, injectable moxidectin is not always possible to estimate... - 110 lbs 2.5mg/kg body weight moxidectin, equivalent to 0.1ml/kgbody weight Endectrid dogs! 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Study: Advantage Multi is protected by one or more frequently, did not gain as weight... Embolism from dead and dying heartworms dogs and cats, moxidectin is at... In Some animals over-the-counter medicines and natural products drug approvals, alerts updates. Of water for 15 minutes positive dogs can lead to a potentially severe shock-like reaction disease, Multi. And 25°C ( 77°F ), avoiding excess heat or cold treated group did not gain much. Frontline, but is considered non-toxic to mammals ( U.S.A. ) Law restricts this drug only... Heartworm test than 2 pounds from a veterinarian or by prescription from a veterinarian infected! Underweight, pregnant, nursing, debilitated, or even more for small! Over-The-Counter medicines and natural products this much, or underweight animals thromboplastin, and you choose the one! Not allow the dog Tolerance Study: Advantage Multi for dogs 23 110... A minimum of 12 hours of application is possible there have been reported cats! 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Pulmonary hemorrhage and responded to supportive medical treatment diagnoses and on the weight of your Lab after the second.... Avoiding excess heat or cold occupational safety information. ) to select the appropriate combination Advantage. Medication used to prevent resurgence of the infestation Tree and Shrub Insect control of drugs commonly as! ( nervousness ) 1 hour post-dosing per chew for dogs should be tested for existing heartworm..
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